Dr. Wolfe currently serve as the Branch Chief for the Vaccine Program in support of the CBRN Division of the Biomedical Advanced Research and Development Authority (BARDA). In doing so, he leads the advanced development and management of complex vaccine projects targeting biological threats. The branch is comprised of team of interdisciplinary experts providing technical oversight of the manufacturing, testing, clinical, non-clinical, and regulatory aspects of these vaccine programs. He leads a program of vaccines targeting priority biological threats, leading them across the ‘valley of death’ into advanced development and ultimately to FDA licensure. His efforts have been a key aspect in the licensure of vaccines against Ebola and smallpox as well as the Emergency Use Authorization of COVID-19 vaccines. He and his team continues to improve the preparedness posture for the United States in the event of a biological attack or outbreak. His background includes a Ph.D. in Pathobiology, studying mechanisms of vaccine-mediated immunity and vaccine escape.